2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105321R
    PBT 1033 (Standard) 747408-78-2 98%
    PBT 1033 (Standard) is the analytical standard of PBT 1033. This product is intended for research and analytical applications. PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria.
    PBT 1033 (Standard)
  • HY-105327R
    P11149 (Standard) 164724-79-2
    P11149 (Standard) is the analytical standard of P11149 (HY-105327). This product is intended for research and analytical applications. P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease.
    P11149 (Standard)
  • HY-105343R
    BW-180C (Standard) 63631-40-3 98%
    BW-180C (Standard) is the analytical standard of BW-180C (HY-105343). This product is intended for research and analytical applications. BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury.
    BW-180C (Standard)
  • HY-105412A
    RU 52583 123829-33-4 98%
    RU 52583 is an oral bioactive antagonist of alpha 2-adrenergic receptor. RU 52583 possesses cognition-enhancing properties in rats with damage to the septohippocampal system.
    RU 52583
  • HY-105445R
    CP-113818 (Standard) 135025-12-6
    CP-113818 (Standard) is the analytical standard of CP-113818 (HY-105445). This product is intended for research and analytical applications. CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease.
    CP-113818 (Standard)
  • HY-105584R
    Tolycaine (Standard) 3686-58-6
    Tolycaine (Standard) is the analytical standard of Tolycaine (HY-105584). This product is intended for research and analytical applications. Tolycaine is a local agent that can suppress or relieve pain. Tolycaine also induces a convulsive response in experimental animals.
    Tolycaine (Standard)
  • HY-10562AR
    Ketanserin tartrate (Standard) 83846-83-7 98%
    Ketanserin (tartrate) (Standard) is the analytical standard of Ketanserin (tartrate). This product is intended for research and analytical applications. Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
    Ketanserin tartrate (Standard)
  • HY-105670R
    PHA-543613 (Standard) 478149-53-0 98%
    PHA-543613 (Standard) is the analytical standard of PHA-543613 (HY-105670). This product is intended for research and analytical applications. PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
    PHA-543613 (Standard)
  • HY-105685R
    SRX246 (Standard) 512784-93-9
    SRX246 (Standard) is the analytical standard of SRX246 (HY-105685). This product is intended for research and analytical applications. SRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders.
    SRX246 (Standard)
  • HY-105710R
    Tropatepine (Standard) 27574-24-9 98%
    Tropatepine (Standard) is the analytical standard of Tropatepine (HY-105710). This product is intended for research and analytical applications. Tropatepine is an orally active anticholinergic agent and can be used in the research of neurological diseases such as Parkinson's disease and extrapyramidal syndromes.
    Tropatepine (Standard)
  • HY-105808R
    Furobufen (Standard) 38873-55-1 98%
    Furobufen (Standard) is the analytical standard of Furobufen. This product is intended for research and analytical applications. Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue.
    Furobufen (Standard)
  • HY-105854A
    Pipoxolan 23744-24-3 98%
    Pipoxolan is an orally active smooth muscle relaxant, anti-inflammatory agent and anticancer agent. Pipoxolan modulates PI3K/AKT signaling pathways, and reduces the levels of Ras/MEK/p-ERK, MMP-2 and MMP-9. Pipoxolan inhibits pro-inflammatory transcription factor pathways, activates Nrf2/HO-1, and suppresses the production of pro-inflammatory mediators. Pipoxolan induces ROS generation, endogenous mitochondrial Apoptosis, and G0/G1 cell cycle arrest. Pipoxolan reduces cerebral infarction size and inhibits intimal hyperplasia. Pipoxolan can be used in research related to cerebral ischemia, intimal hyperplasia, oral squamous cell carcinoma, leukemia and lung cancer.
    Pipoxolan
  • HY-105856R
    Thozalinone (Standard) 655-05-0
    Thozalinone (Standard) is the analytical standard of Thozalinone (HY-105856). This product is intended for research and analytical applications. Thozalinone is an orally active antidepressant agent. Thozalinone induces the release of Norepinephrine (HY-13715) and dopamine.
    Thozalinone (Standard)
  • HY-105896R
    SB399885 (Standard) 402713-80-8
    SB399885 (Standard) is the analytical standard of SB399885 (HY-105896). This product is intended for research and analytical applications. SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties.
    SB399885 (Standard)
  • HY-106003R
    GSK356278 (Standard) 720704-34-7 98%
    GSK356278 (Standard) is the analytical standard of GSK356278 (HY-106003). This product is intended for research and analytical applications. GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory activity, and exhibits anxiolytic and cognition-enhancing effects.
    GSK356278 (Standard)
  • HY-106025R
    Radequinil (Standard) 219846-31-8 98%
    Radequinil (Standard) is the analytical standard of Radequinil (HY-106025). This product is intended for research and analytical applications. Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively.
    Radequinil (Standard)
  • HY-106157R
    Donitriptan (Standard) 170912-52-4
    Donitriptan (Standard) is the analytical standard of Donitriptan (HY-106157). This product is intended for research and analytical applications. Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively.
    Donitriptan (Standard)
  • HY-106246R
    Pruvanserin (Standard) 443144-26-1 98%
    Pruvanserin (Standard) is the analytical standard of Pruvanserin (HY-106246). This product is intended for research and analytical applications. Pruvanserin (EMD 281014 free acid) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia.
    Pruvanserin (Standard)
  • HY-106353R
    Smilagenin (Standard) 126-18-1 98%
    Smilagenin (Standard) is the analytical standard of Smilagenin. This product is intended for research and analytical applications. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD.
    Smilagenin (Standard)
  • HY-106397A
    Delucemine hydrochloride 186495-99-8 98%
    Delucemine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine hydrochloride can be used as an antidepressant.
    Delucemine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity